A trajetória esquecida da fotógrafa Margaret Michaelis: entrevista com Helen Ennis * The forgotten history of photographer Margaret Michaelis: interview with Helen Ennis

Helen.

A conversation with Helen Hobbs.

Helen Hobbs, an HHMI investigator, professor at the University of Texas Southwestern Medical Center, and director of the Dallas Heart Study, is best known for her research focused on identifying genetic factors that predispose people to developing metabolic disorders and heart disease. By studying outliers in the Dallas Heart Study, Hobbs (Figure 1) uncovered a genetic defect responsible for lo...

A Conversation with Helen Sharman

Helen Sharman was driving around London in her car in 1989 when she first heard a radio advertisement asking for applicants for a project to send the first British national to space, specifically to the Soviet Union’s Mir space station. A few years out from receiving her chemistry degree, Sharman was working as a food technologist at Mars, the confectionery company, on a chocolate research proj...

A Conversation with Margaret Faul

G reen chemistry aims to minimize impact on the environment, but it can also save manufacturers time and money, making it good for the bottom line. Recognizing this, many pharmaceutical companies have shifted toward green processes for drug discovery and development in the past decade. Margaret Faul, a synthetic organic chemist by training, led this move at Amgen, one of the world’s largest bio...

Michaelis 29_8

The proteasome inhibitor bortezomib (Velcade®) was recently approved for the treatment of therapy-refractive multiple myeloma and is under investigation for numerous other types of cancer. A phase I clinical trial in paediatric patients resulted in tolerable toxicity. Since the emergence of chemoresistance represents one of the major drawbacks in cancer therapy, we investigated the influence of...